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Reversibility and Access: A Two-Axis Framework for Glucagon-Like Peptide-1 Receptor Agonists Across the Neurological Spectrum, and a Falsifiable Analgesic Hypothesis for Chronic Migraine

2026-07-17

Abstract excerpt

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have moved rapidly from metabolic medicine into neurology, but the evidence to mid-2026 refuses to resolve into a single narrative of neuroprotection. Large cardiovascular outcome trials establish these drugs for ischaemic stroke prevention, whereas rigorous phase 3 trials in Parkinson's disease and Alzheimer's disease found no effect on clinical progression de...

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Literature Corpus work
0e379d1e-0d01-50e6-a35a-dcaf19c2857a
DOI
10.20944/preprints202607.1279.v1
Open publication

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