Article

Glucagon-Like Peptide-1 Receptor Agonists in Chronic Migraine: A Convergent Disease-Modification Hypothesis

2026-05-14

Abstract excerpt

Chronic migraine is increasingly understood as a network-level disorder in which trigeminovascular nociception is sustained by metabolic, inflammatory, and macro-network dysfunction rather than by an isolated headache mechanism. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), originally developed for type 2 diabetes and obesity, engage receptors expressed in choroid plexus, cortex, hippocampus, thalamus, and...

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Literature Corpus work: 9c6ee4c2-5c06-5c6e-8999-1db96104cde2
DOI: 10.20944/preprints202605.0916.v1

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