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Chronic Migraine as an Emergent Systems Failure: Integrating Upstream Neuroimmunology, Gut–Brain Dysregulation, and Computational Chronification

2026-07-16

Abstract excerpt

Chronic migraine affects 1–2% of the global population and is the leading cause of neurological disability in women younger than 50. Calcitonin gene–related peptide (CGRP)-targeting monoclonal antibodies and gepants represent the first disease-specific preventive therapies, yet in the registration trials in chronic migraine roughly six in ten treated patients still fail to reach a 50% reduction in monthly headache...

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Literature Corpus work
b4ed7d74-fea9-5c06-8280-e289d02dd1d4
DOI
10.20944/preprints202605.1223.v2
Open publication

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