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Time-Resolved Transcriptomics Reveal Spliceosomal Disruption and Senescence Pathways in Crocin-Treated Hepatocellular Carcinoma Cells

2025-08-07

Abstract excerpt

Saffron-derived crocin exhibits anti-cancer properties, but the pathways underlying its effects remain incompletely characterized. Here, we utilized a high-dose perturbation strategy (1–2 mM crocin) to probe maximal pathway engagement in HepG2 hepatocellular carcinoma cells via time-series transcriptomics. We treated cells for 2, 6, 12, and 24 h and analyzed transcriptomic and splicing profiles at each timepoint....

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Literature Corpus work
64fe7747-8222-5920-b303-8c5c194314c6
DOI
10.1101/2025.08.05.668798
Open publication

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Time-Resolved Transcriptomics Reveal Spliceosomal Disruption and Senescence Pathways in Crocin-Treated Hepatocellular Carcinoma CellsDOI 10.1101/2025.08.05.668798
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