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Article

RNA-Seq gene expression profiling of HepG2 cells: the influence of experimental factors and comparison with liver tissue

1 Jan 2014

Abstract excerpt

BACKGROUND: Human hepatoma HepG2 cells are used as an in vitro model of the human liver. High-throughput transcriptomic sequencing is an advanced approach for assessing the functional state of a tissue or cell type. However, the influence of experimental factors, such as the sample preparation method and inter-laboratory variation, on the transcriptomic profile has not been evaluated. RESULTS: The...

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PMID: 25511409
DOI: 10.1186/1471-2164-15-1108

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