Article

CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection

2021-07-26

Abstract excerpt

During chronic human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infection prior to AIDS progression, the vast majority of viral replication is concentrated within B cell follicles of secondary lymphoid tissues. We investigated whether infusion of T cells expressing an SIV-specific chimeric antigen receptor (CAR) and the follicular homing receptor, CXCR5, could successfully kill viral-RNA...

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Identifiers and source

Literature Corpus work: 64eb8e1e-7fed-5b33-8744-32a484586e41
DOI: 10.1101/2021.07.26.453803

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