Article

Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H

2022-07-20

Abstract excerpt

<title>Abstract</title> <p>The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement of Quaternary structure) revealed a function for this machinery in the biogenesis of nuclear RNA polymerases. However...

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Literature Corpus work: 64e2b63e-6563-590f-bbdf-a3c9309a53ce
DOI: 10.21203/rs.3.rs-1839772/v1

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