Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer.

BMC cancer - 13 Jul 2016

Lundberg Ida V, Edin Sofia, Eklöf Vincy, Öberg Åke, Palmqvist Richard, Wikberg Maria L

Abstract excerpt

BACKGROUND: To improve current treatment strategies for patients with aggressive colorectal cancer (CRC), the molecular understanding of subgroups of CRC with poor prognosis is of vast importance. SOX2 positive tumors have been associated with a poor patient outcome, but the functional role of SOX2 in CRC patient prognosis is still unclear. METHODS: An in vitro cell culture model expressing SOX2 was used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caco-2 Cells
Share to CDX2 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Kaplan-Meier Estimate

Share to Microsatellite Instability

Share to Neoplasm Grading

Share to Neoplastic Stem Cells

Share to SOXB1 Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27411517
DOI: 10.1186/s12885-016-2509-5
PMCID: PMC4944515

Genes

CDX2
SOX2
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer.PMID 27411517Read ↗

Sox2 is associated with cancer stem-like properties in colorectal cancerSemantic proximity Read ↗

SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancerSemantic proximity Read ↗

Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC PatientsSemantic proximity Read ↗

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.Semantic proximity Read ↗

SOX9 Stem-Cell Factor: Clinical and Functional Relevance in CancerSemantic proximity Read ↗

The prognostic potential of CDX2 in colorectal cancer: Harmonizing biology and clinical practiceSemantic proximity Read ↗

SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer.Semantic proximity Read ↗

<scp>SOX</scp>2 is required to maintain cancer stem cells in ovarian cancerSemantic proximity Read ↗

Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2Semantic proximity Read ↗

Regulation of cancer stem cell properties, angiogenesis, and vasculogenic mimicry by miR-450a-5p/SOX2 axis in colorectal cancerSemantic proximity Read ↗

Prognostic implication of SOX2 expression in small intestinal adenocarcinomaSemantic proximity Read ↗

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.