Article

Epigenetic regulation affects fertility in <i>Drosophila</i> : toward the production of infertile models

2018-05-08

Abstract excerpt

We have revealed that the chorion gene clusters amplify by repeatedly initiating DNA replication from chorion gene amplification origins in the response to developmental signals, through the transcription factors in Drosophila ovarian follicle cells. Orc1, Orc2, and Cdc6 are forms of DNA replication machinery, which are conserved from yeast to humans; and Orc1 and Orc2 mutants are lethal. Overexpression of Orc1 o...

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Literature Corpus work: 64c7e1a9-ac14-5864-9a62-132d08c7b7e1
DOI: 10.1101/317123

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