Article

scOPE identifies which driver-associated expression programs transfer from bulk tumors to single cells

2026-07-26

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) resolves the phenotypic heterogeneity of tumors but rarely observes the somatic mutations that drive it: a variant is legible only where its gene is expressed, the mutant allele is transcribed, and reads span the variant site, so an absent variant read is fundamentally ambiguous. Bulk tumor cohorts have the opposite profile—matched genotype and expression for hundreds of pati...

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Literature Corpus work: 5131afb0-4a8f-5b61-a0fb-da37ccd29f37
DOI: 10.64898/2026.07.24.740598

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