Article

Flow in fetoplacental microvessels in vitro enhances perfusion, barrier function, and matrix stability

2023-07-21

Abstract excerpt

Proper placental vascularization is vital for pregnancy outcomes, but assessing it with animal models and human explants has limitations. Here, we present a 3D in vitro model of human placenta terminal villi that includes fetal mesenchyme and vascular endothelium. By co-culturing HUVEC, placental fibroblasts, and pericytes in a macro-fluidic chip with a flow reservoir, we generate fully perfusable fetal microvess...

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Literature Corpus work: 64b22c3b-e18f-5af0-bf14-39a29bad2e30
DOI: 10.1101/2023.07.19.549736

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