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SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication

16 Feb 2023

Abstract excerpt

Serine incorporator protein 5 (SERINC5) is a key innate immunity factor that operates in the cell to restrict the infectivity of certain viruses. Different viruses have developed strategies to antagonize SERINC5 function but, how SERINC5 is controlled during viral infection is poorly understood. Here, we report that SERINC5 levels are reduced in COVID-19 patients during the infection by SARS-CoV-2 and, since no...

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PMID: 36876111
DOI: 10.3389/fmicb.2023.1066493

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