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Article

Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine

24 May 2016

Abstract excerpt

DNA damage can significantly modulate expression of the affected genes either by direct structural interference with transcription components or as a collateral outcome of cellular repair attempts. Thus, DNA glycosylases of the base excision repair (BER) pathway have been implicated in negative transcriptional response to several spontaneously generated DNA base modifications, including a common oxidative DNA...

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PMID: 27220469
DOI: 10.1093/nar/gkw473

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