Article

H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives

2020-08-22

Abstract excerpt

The ‘snp-wise mean model’ of Multi-marker Analysis of GenoMic Annotation is often used to perform gene-level testing for association with disease and other phenotypes. This methodology, in turn, forms the foundation for H-MAGMA. Unfortunately, that foundation is unsound, with implications for H-MAGMA results published in Nature Neuroscience regarding genes associated with psychiatric disorders: e.g., only 125 of...

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Literature Corpus work: 646a5e04-6a09-5b23-a44b-d8861fd080e1
DOI: 10.1101/2020.08.20.260224

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