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Article

"Guilt by association" is not competitive with genetic association for identifying autism risk genes.

Scientific reports - 5 Aug 2021

Gunning Margot, Pavlidis Paul

Abstract excerpt

Discovering genes involved in complex human genetic disorders is a major challenge. Many have suggested that machine learning (ML) algorithms using gene networks can be used to supplement traditional genetic association-based approaches to predict or prioritize disease genes. However, questions have been raised about the utility of ML methods for this type of task due to biases within the data, and poor...

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Identifiers

PMID: 34354131
DOI: 10.1038/s41598-021-95321-y
PMCID: PMC8342445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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