Article
Many Phenotypes Without Many False Discoveries: Error Controlling Strategies for Multitrait Association Studies.
Genetic epidemiology - 1 Jan 2016
Peterson Christine B, Bogomolov Marina, Benjamini Yoav, Sabatti Chiara
Abstract excerpt
The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection of hypotheses, probing the existence of association between each of the traits and hundreds of thousands of genotyped variants. Appropriate multiplicity adjustment is crucial to guarantee replicability of findings, and the false discovery rate (FDR) is...
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