Article

Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission

2025-10-27

Abstract excerpt

Simian immunodeficiency viruses (SIVs) have crossed from apes to humans at least four times, but only one event gave rise to the AIDS pandemic. The host barriers that pandemic HIV-1 group M ( major ) strains overcame to spread efficiently in humans remain poorly understood. To identify such barriers, we performed CRISPR-Cas9 screens driven by the replication efficiency of SIVcpz, the chimpanzee precursor of HIV-1...

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Literature Corpus work: 08413ee4-f126-5903-a0cf-422b07647be7
DOI: 10.1101/2025.10.27.684817

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