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CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector

9 Nov 2020

Abstract excerpt

A vaccine for smallpox is no longer administered to the general public, and there is no proven, safe treatment specific to poxvirus infections, leaving people susceptible to infections by smallpox and other zoonotic Orthopoxviruses such as monkeypox. Using vaccinia virus (VACV) as a model organism for other Orthopoxviruses, CRISPR-Cas9 technology was used to target three essential genes that are conserved across...

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PMID: 33168908
DOI: 10.1038/s41598-020-76449-9

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