Article
Triad of human cellular proteins, IRF2, FAM111A, and RFC3, restrict replication of orthopoxvirus SPI-1 host-range mutants.
Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017
Panda Debasis, Fernandez Daniel J, Lal Madhu, Buehler Eugen, Moss Bernard
Abstract excerpt
Viruses and their hosts can reach balanced states of evolution ensuring mutual survival, which makes it difficult to appreciate the underlying dynamics. To uncover hidden interactions, virus mutants that have lost defense genes may be used. Deletion of the gene that encodes serine protease inhibitor 1 (SPI-1) of rabbitpox virus and vaccinia virus, two closely related orthopoxviruses, prevents their efficient...
Topics
- A549 Cells
- Humans
- Interferon Regulatory Factor-2
- Microarray Analysis
- Mutation
- Orthopoxvirus
- Poxviridae Infections
- Receptors, Virus
- Replication Protein C
- Serpins
- Viral Proteins
- Virus Replication