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Article

Triad of human cellular proteins, IRF2, FAM111A, and RFC3, restrict replication of orthopoxvirus SPI-1 host-range mutants.

Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017

Panda Debasis, Fernandez Daniel J, Lal Madhu, Buehler Eugen, Moss Bernard

Abstract excerpt

Viruses and their hosts can reach balanced states of evolution ensuring mutual survival, which makes it difficult to appreciate the underlying dynamics. To uncover hidden interactions, virus mutants that have lost defense genes may be used. Deletion of the gene that encodes serine protease inhibitor 1 (SPI-1) of rabbitpox virus and vaccinia virus, two closely related orthopoxviruses, prevents their efficient...

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Source

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Identifiers

PMID: 28320935
DOI: 10.1073/pnas.1700678114
PMCID: PMC5389286

Genes

RFC3
RFC1
RFC2
RFC4
RFC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Triad of human cellular proteins, IRF2, FAM111A, and RFC3, restrict replication of orthopoxvirus SPI-1 host-range mutants.PMID 28320935Read ↗

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