Article

Mutational signature analysis predicts bacterial hypermutation and multidrug resistance

2024-06-13

Abstract excerpt

<title>Abstract</title> <p>Bacteria of clinical importance, such as <italic>Pseudomonas aeruginosa</italic>, can become hypermutators upon loss of DNA mismatch repair (MMR) and are clinically correlated with high rates of multidrug resistance (MDR). Here, we demonstrate that hypermutated MMR-deficient <italic>P. aeruginosa</italic> has a unique mutational signature and rapidly acquires MDR upon repeated exposure...

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Literature Corpus work: 64452f85-ea7d-5ae9-a19c-b39dc9c93dbe
DOI: 10.21203/rs.3.rs-4529716/v1

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