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Article

Mutational signature analysis predicts bacterial hypermutation and multidrug resistance.

Nature communications - 2 Jan 2025

Hall Kalen M, Williams Leonard G, Smith Richard D, Kuang Erin A, Ernst Robert K, Bojanowski Christine M, Wimley William C, Morici Lisa A, Pursell Zachary F

Abstract excerpt

Bacteria of clinical importance, such as Pseudomonas aeruginosa, can become hypermutators upon loss of DNA mismatch repair (MMR) and are clinically correlated with high rates of multidrug resistance (MDR). Here, we demonstrate that hypermutated MMR-deficient P. aeruginosa has a unique mutational signature and rapidly acquires MDR upon repeated exposure to first-line or last-resort antibiotics. MDR acquisition was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39746975
DOI: 10.1038/s41467-024-55206-w
PMCID: PMC11695600

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