Article
Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 1997
Anzini P, Neuberg D H, Schachner M, Nelles E, Willecke K, Zielasek J, Toyka K V, Suter U, Martini R
Abstract excerpt
Mutations affecting the connexin 32 (Cx32) gene are associated with the X-linked form of the hereditary peripheral neuropathy Charcot-Marie-Tooth disease (CMTX). We show that Cx32-deficient mice develop a late-onset progressive peripheral neuropathy with abnormalities comparable to those associated with CMTX, thus providing proof of the critical role of Cx32 in the maintenance of peripheral nerve myelin and an...
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