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Article

Connexin channels in Schwann cells and the development of the X-linked form of Charcot-Marie-Tooth disease.

Brain research. Brain research reviews - 1 Apr 2000

Ressot C, Bruzzone R

Abstract excerpt

Charcot-Marie-Tooth disease comprises a group of genetically heterogenous disorders of the peripheral nervous system. The X-linked form of Charcot-Marie-Tooth (CMTX) is associated with mutations in the gene encoding the gap junction protein connexin32 (Cx32), which is expressed in Schwann cells. Immunocytochemical evidence suggests that Cx32 is localized to the incisures of Schmidt-Lanterman and the paranodes of...

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PMID: 10751670
DOI: 10.1016/s0165-0173(99)00081-8

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