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Calcimycin Inhibits Cryptococcus neoformans In Vitro and In Vivo by Targeting the Prp8 Intein Splicing

10 Aug 2022

Abstract excerpt

Drug resistance is a significant concern in the treatment of diseases, including cryptococcosis caused by Cryptococcus neoformans ( Cne ) and Cryptococcus gattii ( Cga ). Alternative drug targets are necessary to overcome drug resistance before it attains a critical stage. Splicing of inteins from pro-protein precursors is crucial for activities of essential proteins hosting intein elements in many organisms,...

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PMID: 35948057
DOI: 10.1021/acsinfecdis.2c00137

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