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Positive and negative feedback regulation of the TGF-β1–SMAD4 axis explains two equilibrium states in human skin aging

2023-07-19

Abstract excerpt

<h4>Summary</h4> Skin homeostasis during aging is critical not only for the appearance but also biological defense of the human body. In this study, we identified thrombospondin-1 (THBS1) and fibromodulin (FMOD) as positive and negative regulators, respectively, of the TGF-β1–SMAD4 axis in human skin aging based on in vitro and in vivo omics analyses and mathematical modeling. Transcriptomic and epigenetic anal...

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Literature Corpus work
e1693c71-b05e-5d08-b122-0454856e7525
DOI
10.1101/2023.07.18.546970
Open publication

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Positive and negative feedback regulation of the TGF-β1–SMAD4 axis explains two equilibrium states in human skin agingDOI 10.1101/2023.07.18.546970
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