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Article

A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model.

Scientific reports - 12 Sept 2017

Daly Conor, Shine Lisa, Heffernan Theresa, Deeti Sudhakar, Reynolds Alison L, O'Connor John J, Dillon Eugène T, Duffy David J, Kolch Walter, Cagney Gerard, Kennedy Breandán N

Abstract excerpt

Controversially, histone deacetylase inhibitors (HDACi) are in clinical trial for the treatment of inherited retinal degeneration. Utilizing the zebrafish dye ucd6 model, we determined if treatment with HDACi can rescue cone photoreceptor-mediated visual function. dye exhibit defective visual behaviour and retinal morphology including ciliary marginal zone (CMZ) cell death and decreased photoreceptor outer...

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Identifiers

PMID: 28900183
DOI: 10.1038/s41598-017-11513-5
PMCID: PMC5595969

Genes

BDNF

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