Requirement of histone deacetylase activity for the expression of critical photoreceptor genes

Abstract excerpt

BACKGROUND: Histone deacetylases (HDACs) play a major role in the regulation of gene transcription, often leading to transcriptional repression, as well as other effects following deacetylation of non-histone proteins. RESULTS: To investigate the role of HDACs in the developing mammalian retina, a general inhibitor of HDACs, trichostatin-A (TSA), was used to treat newborn murine retinae in explant cultures....

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