Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.

doi:10.1038/s41467-026-74190-x

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Article

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.

Nature communications - 23 Jun 2026

Jeffrey Mark, Bartholdson Scott Josefin, Mazumdar Shyamanova, White Richard J, Higginson Ellen, Maes Mailis, Forrest Sally, Pereira-Dias Joana, Parmar Surendra, Heasman-Hunt Emma, Curran Martin D, Polgarova Petra, Herre Jurgen, Wauters Els, Lambrechts Diether, Van Mol Pierre, Jacobs Cato, Wauters Joost, Davenport Emma E, Baker Stephen, Dougan Gordon, Navapurkar Vilas, Conway Morris Andrew

Abstract excerpt

Pneumonia is the leading infectious disease killer worldwide and commonly requires admission to critical care. Despite its prevalence, the underpinning biology of severe pneumonia remains incompletely understood. Here we perform multifaceted assessments of bronchoalveolar transcriptome, cytokines, microbiology, and clinical features to biologically characterise a cohort of patients with suspected severe...

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PMID: 42337236
DOI: 10.1038/s41467-026-74190-x
PMCID: PMC13291267

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STAT3

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