Article

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes

2024-09-03

Abstract excerpt

Pneumonia is the leading infectious disease killer worldwide and commonly requires admission to critical care. Despite its prevalence, the underpinning biology of severe pneumonia remains incompletely understood. We performed multifaceted assessments of bronchoalveolar transcriptome, cytokines, microbiology, and clinical features to biologically dissect a cohort of patients with suspected severe pneumonia. Our dat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e46e11b-f4b7-51cb-bbce-79467d51911f
DOI: 10.1101/2024.09.02.24312971

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypesDOI 10.1101/2024.09.02.24312971Read

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.Semantic proximity Read

Pathogen-specific host responses define distinct pneumonia endotypes in the human lungSemantic proximity Read

A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlasSemantic proximity Read

Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar LavagesSemantic proximity Read

Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesisSemantic proximity Read

Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolutionSemantic proximity Read

Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumoniaSemantic proximity Read

Identification of functional bacterial-viral pneumotypes associated with airway inflammation and all-cause mortality in critically ill patientsSemantic proximity Read

Bronchoalveolar Lavage Single-Cell Transcriptomics Identifies Immune Cells Driving COVID-19 Severity in PatientsSemantic proximity Read

Comparative transcriptomic analyses of peripheral blood mononuclear cells of patients with non-pneumonia and severe pneumonia at 1 year-Long-COVID-19Semantic proximity Read

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19Semantic proximity Read

From clinical phenotypes to cellular mechanisms: a precision medicine framework for COPD.Semantic proximity Read