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p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver

1 Jan 2024

Abstract excerpt

Background: Clinically, the persistence of HBV cccDNA is the major obstacle in anti-HBV therapy.However, the underlying mechanism of HBV cccDNA is poorly understood.The transcriptional factor STAT3 is able to activate HBV replication in liver. Approach & Results:RNA-Seq analysis demonstrated that cucurbitacin I targeting STAT3 was associated with virus replication in liver.HBV-infected human liver chimeric mouse...

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PMID: 39346550
DOI: 10.7150/thno.99407

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