Article
Homeostatic effects of exosomal KLF2 microRNAs : implications for treatment of pulmonary hypertension
2020-01-01
Abstract excerpt
Background. Pulmonary arterial hypertension (PAH) is a severe disorder leading to right heart failure. Recently identified disabling mutations in shear stress-activated transcription factor Krüppel-like factor 2 (KLF2) in hereditary PAH suggest its potential role in the disease. I studied the role of KLF2-induced exosomal microRNAs (miRNAs) in PAH. Methods. Changes in miRNA profile were studied in exosomes purifi...
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Identifiers and source
- Literature Corpus work
- 6391a99b-deea-556b-b98d-d2a60655185b
- DOI
- 10.25560/90801