Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exosomal miR-107 antagonizes profibrotic phenotypes of pericytes by targeting a pathway involving HIF-1α/Notch1/PDGFRβ/YAP1/Twist1 axis in vitro.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2021

Wang Yi-Chun, Xie Han, Zhang Yong-Chang, Meng Qing-He, Xiong Ming-Mei, Jia Ming-Wang, Peng Fang, Tang Dao-Lin

Abstract excerpt

Microvascular pericytes have been demonstrated as an origin for myofibroblasts that produce excessive extracellular matrix (ECM) proteins such as α-smooth muscle actin (α-SMA) and type I collagen (ColIA1) and contribute to pulmonary fibrosis (PF). However, the signaling mechanism responsible for ECM production within pericytes is poorly understood. In this study, we examined exosomal miR-107 in the fibrotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exosomes
Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pericytes

Share to Pulmonary Fibrosis

Share to Receptor, Notch1

Share to Receptor, Platelet-Derived Growth Factor beta

Share to Twist-Related Protein 1

Share to YAP-Signaling Proteins

Source

Identifiers

PMID: 33216617
DOI: 10.1152/ajpheart.00373.2020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exosomal miR-107 antagonizes profibrotic phenotypes of pericytes by targeting a pathway involving HIF-1α/Notch1/PDGFRβ/YAP1/Twist1 axis in vitro.PMID 33216617Read ↗

Exosomes enriched by miR-429-3p derived from ITGB1 modified Telocytes alleviates hypoxia-induced pulmonary arterial hypertension through regulating Rac1 expressionSemantic proximity Read ↗

MicroRNA in Fibrotic Disorders: A Potential Target for Future TherapeuticsSemantic proximity Read ↗

MiRNA, a New Treatment Strategy for Pulmonary FibrosisSemantic proximity Read ↗

β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosisSemantic proximity Read ↗

β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosisSemantic proximity Read ↗

microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat modelSemantic proximity Read ↗

Role of MicroRNAs in TGF-β Signaling Pathway-Mediated Pulmonary FibrosisSemantic proximity Read ↗

Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2Semantic proximity Read ↗

Novel insights into pericyte–myofibroblast transition and therapeutic targets in renal fibrosisSemantic proximity Read ↗

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes microRNA-31-5p Repress Pulmonary Fibrosis via IGFBP7Semantic proximity Read ↗

MicroRNAs in Liver Fibrosis: Unraveling Intercellular Crosstalk and the Regulatory Functions of MicroRNA-223Semantic proximity Read ↗

MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.