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Article

Dynamic Changes in Lung MicroRNA Profiles During the Development of Pulmonary Hypertension due to Chronic Hypoxia and Monocrotaline

28 Jan 2010

Abstract excerpt

OBJECTIVE: MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding "seed" sequences within a target mRNA. Each miRNA is capable of potentially controlling hundreds of genes. The regulation of miRNAs in the lung during the development of pulmonary arterial hypertension (PAH) is unknown. METHODS AND RESULTS: We screened lung miRNA profiles in a longitudinal...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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Share to Pulmonary Hypertension Research and Treatments

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PMID: 20110569
DOI: 10.1161/atvbaha.109.202028

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