Article

Genomic analysis of human polymorphisms affecting drug-protein interactions

2017-03-23

Abstract excerpt

Human genetic variability is thought to account for a substantial fraction of individual biochemical characteristics – in biomedical sense, of individual drug response. However, only a handful of human genetic variants have been linked to medication outcomes. Here, we combine data on drug-protein interactions and human genome sequences to assess the impact of human variation on their binding affinity. Using data f...

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Identifiers and source

Literature Corpus work: 6380f289-b81a-50e8-8701-6be4bcfa5bc9
DOI: 10.1101/119933

Open publication

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