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Article

Immune biomarker landscape and fusion partner-phenotype associations in thoracic and head-and-neck NUT carcinoma.

Frontiers in immunology - 1 Jan 2026

Xiang Shuang, Ye Zhuomiao, Dai Yifan, Shang Shipeng, Yang Dan, Cheng Tao, Deng Chao, Zhang Minghui, Yin Mingzhu

Abstract excerpt

Background: Thoracic and head and neck NUT carcinoma is a rare, highly aggressive NUTM1-rearranged malignancy with substantial diagnostic difficulty, marked phenotypic heterogeneity, and no established biomarker framework for immunotherapy stratification. Although fusion partners may contribute to clinicopathologic diversity, their relationship to phenotype and immune biomarkers remains insufficiently defined....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42292444
DOI: 10.3389/fimmu.2026.1834366
PMCID: PMC13253808

Genes

NUTM1
BRD4
MGA
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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