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Article

AKT regulates NPM dependent ARF localization and p53mut stability in tumors.

Oncotarget - 15 Aug 2014

Hamilton Garth, Abraham Aswin G, Morton Jennifer, Sampson Oliver, Pefani Dafni E, Khoronenkova Svetlana, Grawenda Anna, Papaspyropoulos Angelos, Jamieson Nigel, McKay Colin, Sansom Owen, Dianov Grigory L, O'Neill Eric

Abstract excerpt

Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. Here we describe how NPM and ARF associate in the nucleoplasm to form a MDM2 inhibitory complex. We find that oligomerization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25071014
DOI: 10.18632/oncotarget.2178
PMCID: PMC4171619

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25071014-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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