Article

One Section, Two Worlds: Single-Cell Integration of MALDI-MSI and Spatial Transcriptomics on the Same Single Tissue Section

2025-07-19

Abstract excerpt

Understanding tissue complexity requires spatially resolved multiomic data at single-cell resolution. Here, we present a workflow that integrates high-resolution matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) with Xenium spatial transcriptomics (SPT) on a single tissue section. This one-section strategy ensures exact spatial correspondence between metabolic and transcriptomic fea...

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Identifiers and source

Literature Corpus work: 5e408063-4292-5ca3-a992-44b1dcd9fa38
DOI: 10.1101/2025.07.16.665110

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