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Article

Gaining insight into metabolic diseases from human genetic discoveries.

Trends in genetics : TIG - 1 Dec 2021

Claussnitzer Melina, Susztak Katalin

Abstract excerpt

Human large-scale genetic association studies have identified sequence variations at thousands of genetic risk loci that are more common in patients with diverse metabolic disease compared with healthy controls. While these genetic associations have been replicated in multiple large cohorts and sometimes can explain up to 50% of heritability, the molecular and cellular mechanisms affected by common genetic...

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Identifiers

PMID: 34315631
DOI: 10.1016/j.tig.2021.07.005
PMCID: PMC8578350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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