Article

Pretreatment of aged mice with retinoic acid restores alveolar regeneration via upregulation of reciprocal PDGFRA signaling

2020-05-08

Abstract excerpt

<h4>Objectives</h4> Idiopathic Pulmonary Fibrosis (IPF) primarily affects the aged population and is characterized by failure of alveolar regeneration leading to loss of alveolar type 1 cells (AT1). Aged mouse models of lung repair have demonstrated that regeneration fails with increased age. Mouse and rat lung repair models have shown retinoic acid (RA) treatment can restore alveolar regeneration. Herein we seek...

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Literature Corpus work: 6330923a-3679-577e-ab4f-b42ffd6f6f0c
DOI: 10.1101/2020.05.06.080994

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