Article

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

2021-03-29

Abstract excerpt

Elucidating the wiring diagram of the human cell is a central goal of the post-genomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks...

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Identifiers and source

Literature Corpus work: 632029cf-ab71-585b-8a65-d68af8af6dd3
DOI: 10.1101/2021.03.29.437450

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