Article

Alzheimer’s disease-associated <i>TM2D</i> genes regulate Notch signaling and neuronal function in <i>Drosophila</i>

2021-04-20

Abstract excerpt

TM2 domain containing (TM2D) proteins are conserved in metazoans and encoded by three separate genes in each species. Rare variants in TM2D3 are associated with Alzheimer’s disease (AD) and its fly ortholog almondex is required for embryonic Notch signaling. However, the functions of this gene family remain elusive. We knocked-out all three TM2D genes ( almondex, CG11103/amaretto , CG10795/biscotti ) in Dros...

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Literature Corpus work: 631cbb91-3793-5c60-81ba-b80731a2734e
DOI: 10.1101/2021.04.20.440660

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