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Article

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.

Human molecular genetics - 15 Feb 2014

Shulman Joshua M, Imboywa Selina, Giagtzoglou Nikolaos, Powers Martin P, Hu Yanhui, Devenport Danelle, Chipendo Portia, Chibnik Lori B, Diamond Allison, Perrimon Norbert, Brown Nicholas H, De Jager Philip L, Feany Mel B

Abstract excerpt

Using a Drosophila model of Alzheimer's disease (AD), we systematically evaluated 67 candidate genes based on AD-associated genomic loci (P < 10(-4)) from published human genome-wide association studies (GWAS). Genetic manipulation of 87 homologous fly genes was tested for modulation of neurotoxicity caused by human Tau, which forms neurofibrillary tangle pathology in AD. RNA interference (RNAi) targeting 9 genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24067533
DOI: 10.1093/hmg/ddt478
PMCID: PMC3900103

Genes

FERMT2
CELF1
ITGA9
ITGAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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