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Article

TM2D genes regulate Notch signaling and neuronal function in Drosophila.

PLoS genetics - 1 Dec 2021

Salazar Jose L, Yang Sheng-An, Lin Yong Qi, Li-Kroeger David, Marcogliese Paul C, Deal Samantha L, Neely G Gregory, Yamamoto Shinya

Abstract excerpt

TM2 domain containing (TM2D) proteins are conserved in metazoans and encoded by three separate genes in each model organism species that has been sequenced. Rare variants in TM2D3 are associated with Alzheimer's disease (AD) and its fly ortholog almondex is required for embryonic Notch signaling. However, the functions of this gene family remain elusive. We knocked-out all three TM2D genes (almondex,...

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Identifiers

PMID: 34905536
DOI: 10.1371/journal.pgen.1009962
PMCID: PMC8714088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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