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Article

Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Yang Sheng-An, Salazar Jose L, Li-Kroeger David, Yamamoto Shinya

Abstract excerpt

Rare variants in the many genes related to Notch signaling cause diverse Mendelian diseases that affect myriad organ systems. In addition, genome- and exome-wide association studies have linked common and rare variants in Notch-related genes to common diseases and phenotypic traits. Moreover, somatic mutations in these genes have been observed in many types of cancer, some of which are classified as oncogenic and...

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Identifiers

PMID: 35674905
DOI: 10.1007/978-1-0716-2201-8_19
PMCID: PMC9396741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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