Article

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

2021-09-30

Abstract excerpt

<h4>ABSTRACT</h4> The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient with a novel mutation in the KIF22 tail. We demonstrate that pathogenic mutations do not result in a loss of KIF22’s funct...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62fc9dc4-4580-57a0-8dd8-1279778a0fc7
DOI: 10.1101/2021.09.29.462402

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregationDOI 10.1101/2021.09.29.462402Read

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation.Semantic proximity Read

Medically unexplored storiesSemantic proximity Read

Novel KIF22 Variants Disrupt Mitosis in Human Chondrocytes and Expand SEMDJL2 MechanismsSemantic proximity Read

Involvement of kinesins in skeletal dysplasia: a review.Semantic proximity Read

The kinesin-4 family member KIF27 regulates mitotic progression, cytokinesis and genome stabilitySemantic proximity Read

Kinesin family member Kif23 regulates cytokinetic division and maintains neural stem/progenitor cell pool in the developing neocortexSemantic proximity Read

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-bindingSemantic proximity Read

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progressionSemantic proximity Read

csi2p modulates microtubule dynamics and organizes the bipolar spindle for chromosome segregation.Semantic proximity Read

KIF5B drives meiotic chromosome dynamics via interaction with the KASH5-LINC complexSemantic proximity Read

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosisSemantic proximity Read

Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest.Semantic proximity Read