Article

Medically unexplored stories

2009-09-01

Abstract excerpt

<h3>ABSTRACT</h3> The chromokinesin KIF22 uses plus end-directed motility and direct binding to chromosome arms to generate pushing forces that contribute to mitotic chromosome congression and alignment. Mutations in the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient with a novel mutation in the coiled-coil domain of the KIF2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce017875-3678-5734-bda2-3626885e2175
DOI: 10.1136/pgmj.2009.087411

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Medically unexplored storiesDOI 10.1136/pgmj.2009.087411Read

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregationSemantic proximity Read

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation.Semantic proximity Read

Novel KIF22 Variants Disrupt Mitosis in Human Chondrocytes and Expand SEMDJL2 MechanismsSemantic proximity Read

Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteinsSemantic proximity Read

Loss-of-function of kinesin-5 KIF11 causes microcephaly, chorioretinopathy, and developmental disorders through chromosome instability and cell cycle arrest.Semantic proximity Read

Transient lagging chromosomes cause primary microcephalySemantic proximity Read

Involvement of kinesins in skeletal dysplasia: a review.Semantic proximity Read

Kinetochore Malfunction in Human Pathologies.Semantic proximity Read

Kinesin family member Kif23 regulates cytokinetic division and maintains neural stem/progenitor cell pool in the developing neocortexSemantic proximity Read

Kif2C safeguards radial glial integrity to prevent cortical malformationSemantic proximity Read

Germline Missense Variants in <i>CDC20</i> Result in Aberrant Mitotic Progression and Familial CancerSemantic proximity Read

Interrupted/bipartite clavicle as a diagnostic clue in Kabuki syndrome.Semantic proximity Read