Article

Energy-Based Systematic Modeling of Adaptive Immune Repertoire Behavior: Study on Cell Proliferation & Somatic Hypermutation process

2024-05-15

Abstract excerpt

Monitoring and describing the adaptive immune repertoire(IR) for disease detection and diagnosis is essential in healthcare research. Many phenomenon have been observed to generalize the static property of IR, but the mathematical description of the formation and dynamic changes of IR still lacks research. Here, we present a mathematical and physical model to interpret the cell proliferation and somatic hypermutat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62e9f168-70e8-5ed2-b66f-2b7e1ea54002
DOI: 10.1101/2024.05.13.593908

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Energy-Based Systematic Modeling of Adaptive Immune Repertoire Behavior: Study on Cell Proliferation & Somatic Hypermutation processDOI 10.1101/2024.05.13.593908Read

Heterogeneity in immune responses: from populations to single cells.Semantic proximity Read

A mathematical model for immune and autoimmune response mediated by<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si88.gif" display="inline" overflow="scroll"><mml:mi>T</mml:mi></mml:math>-cellsSemantic proximity Read

The S(c)ensory Immune System TheorySemantic proximity Read

Mathematical Model of Pancreatic Cancer Cell Dynamics Considering the Set of Sequential Mutations and Interaction With the Immune SystemSemantic proximity Read

A race between tumor immunoescape and genome maintenance selects for optimum levels of (epi)genetic instability.Semantic proximity Read

Fluctuating fitness shapes the clone-size distribution of immune repertoires.Semantic proximity Read

Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics via Phenotypic DifferentiationSemantic proximity Read

Modeling and simulation of genotypic Tumor Mutational Burden and Phenotypic Immunogenicity biomarkers in cancer immunoediting with Ising-Hamiltonian characterization.Semantic proximity Read

Fluctuating fitness shapes the clone size distribution of immune repertoiresSemantic proximity Read

A novel computational tool for tracking cancer energy hijacking from immune cellsSemantic proximity Read

Regulated somatic hypermutation enhances antibody affinity maturationSemantic proximity Read

A Multiscale Spatial Modeling Framework for the Germinal Center ResponseSemantic proximity Read