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Modeling and simulation of genotypic Tumor Mutational Burden and Phenotypic Immunogenicity biomarkers in cancer immunoediting with Ising-Hamiltonian characterization.

Computers in biology and medicine - 1 Mar 2025

Rojas-Domínguez Alfonso, Martínez-Vargas Irving Ulises, Alvarado-Mentado Matías

Abstract excerpt

BACKGROUND AND OBJECTIVE: In the Tumor Micro-Environment, cancer progression and its relationship with the Immune System (IS) are described in terms of cancer immunoediting (CI) phases, each of which is characterized by different types and levels of interaction between the tumor cells and elements of the IS, such as CD8+T cells. Said interactions are governed by genotypical (Tumor Mutational Burden, TMB) and...

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PMID: 39894008
DOI: 10.1016/j.compbiomed.2025.109717

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