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Article

Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling.

The Journal of biological chemistry - 25 Jan 2013

Yang Lu, Li Yun, Ding Yi, Choi Kyoung-Soo, Kazim A Latif, Zhang Yuesheng

Abstract excerpt

Prolidase, also known as Xaa-Pro dipeptidase or peptidase D (PEPD), is a ubiquitously expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus. In this article, however, we demonstrate that PEPD directly binds to and activates epidermal growth...

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Source

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Identifiers

PMID: 23212918
DOI: 10.1074/jbc.M112.429159
PMCID: PMC3554907

Genes

EGFR
PEPD
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23212918-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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