Article

EGFR-Driven Phenotypes Dictate Differential Therapeutic Response to Radiotherapy and Temozolomide in Glioblastoma

2025-11-25

Abstract excerpt

Despite the established Stupp regimen, glioblastoma (GBM) remains a highly lethal cancer with a 5-year survival rate below 10%. The epidermal growth factor receptor (EGFR) is frequently amplified or mutated in GBM, and we have previously shown that different EGFR statuses correlate with distinct tumor phenotypes and responses to temozolomide (TMZ). In this study, we investigated the differential response of two mo...

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Literature Corpus work: 62c34356-0917-5cac-b2a6-5ac7304e025f
DOI: 10.1101/2025.11.22.689881

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